JCEM: Gender-specific association of superficial and deep subcutaneous adipose tissue with liver steatosis and metabolic characteristics

The subcutaneous fat tissue (SAT) is not homogeneous because the fascia separates the deep SAT (dSAT) from the superficial SAT (sSAT)
.

Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, which aims to assess the sex-specific association of sSAT and dSAT with liver steatosis and metabolic syndrome in overweight individuals

Metabolic syndrome

The researchers recruited 285 individuals with a BMI ≥ 27 kg/m2, aged 55-81 years old
.

Perform abdominal magnetic resonance imaging near the L4-L5 level to measure the volume of VAT, dSAT, and sSAT

Compared with women adjusted according to BMI (50.
3 cm3 vs.
97.
0 cm3 for men and women, p<0.
001)
.

In univariate analysis, dSAT was significantly correlated with liver fat content (standard β=0.

In addition, in the multivariate analysis, there was a negative correlation between male dSAT and HDL-c (standard β=-0.
165, p=0.
038)
.

In women with a BMI of 30-40 kg/m2, in a multivariate model adjusted for age, alcohol consumption, and other abdominal fat compartments, VAT was positively correlated with liver fat content (standard β=-0.

It can be seen that in men, dSAT is associated with liver steatosis and poor metabolic characteristics, such as lower HDL- cholesterol levels; while in obese women, there is a beneficial correlation between sSAT and liver fat content

In men, dSAT is associated with liver steatosis and poor metabolic characteristics, such as lower HDL- cholesterol levels; in obese women, there is a beneficial correlation between sSAT and liver fat content, cholesterol

Original source:

Original source:

Tessa Brand.

Superficial versus Deep Subcutaneous Adipose Tissue: Sex -Specific Associations with Hepatic Steatosis and Metabolic Traits in this message