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Background: In obesity, adipose tissue responses to natural cues or challenges, such as feeding and related gut hormones, are not fully understood
Background: In obesity, adipose tissue responses to natural cues or challenges, such as feeding and related gut hormones, are not fully understood
In the presence of insulin, GIP increases blood flow in subcutaneous adipose tissue (SAT)
Objective: To study the effect of diet and GIP on VAT and SAT perfusion before and after bariatric surgery in obese patients with T2DM
Materials and methods: We recruited 10 obese subjects with T2DM and 10 control subjects who were scheduled to undergo bariatric surgery
Results: Obese subjects were less responsive to meal (p=0.
Figure 1 SAT and VAT blood flow at baseline, 20 and 50 minutes after mixed meals, or after initiation of GIP infusion
Figure 1 SAT and VAT blood flow at baseline, 20 and 50 minutes after mixed meals, or after initiation of GIP infusion
Figure 2 Changes in blood glucose, insulin, GIP, and GLP-1 concentrations induced by mixed dietary stimulation and GIP infusion before and after bariatric surgery in control and obese subjects
Figure 2 Changes in blood glucose, insulin, GIP, and GLP-1 concentrations induced by mixed dietary stimulation and GIP infusion before and after bariatric surgery in control and obese subjects
Table 1 Anthropometric measurements of subjects and control subjects before and after bariatric surgery
Conclusions: In obese subjects with T2DM, the vasodilatory effects of GIP and meal were attenuated in SAT but not in VAT
Conclusions: In obese subjects with T2DM, the vasodilatory effects of GIP and meal were attenuated in SAT but not in VAT
Original source: Saari T, Koffert J, Honka H, et al.
Obesity associated blunted subcutaneous adipose tissue blood flow after meal is improved after bariatric surgery .
J Clin Endocrinol Metab 2022 Apr 01.
Obesity associated blunted subcutaneous adipose tissue blood flow after meal is improved after bariatric surgery
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