JCEM: Ovarian Reserve Biomarkers and Menstrual Cycle Length

Although age-related changes in menstrual cycle length are well known, it is unclear whether AMH or other biomarkers of ovarian reserve are directly related to cycle length.

Recently, the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, published a research article aimed at clarifying the relationship between ovarian reserve biomarkers and menstrual cycle length.

The researchers performed a secondary analysis using prospective study (TTC) data on timing of pregnancy, and used linear mixed and marginal models to analyze age-independent correlations between cycle length and biomarkers of ovarian reserve.

The study recruited women between 30 and 44 years of age who were not pregnant and tried to conceive for less than 3 months.

Multivariate analysis included 1,880 menstrual cycles from 632 women.

It can be seen that the increase in AMH level is related to the prolonged menstrual cycle, because the prolongation of the follicular phase and the luteal phase has nothing to do with age.

Benjamin S Harris.