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Weight regain prevention after successful weight loss is one of the greatest challenges for people who are overweight or obese, as weight regain after weight loss is almost inevitable
.
Studies have shown that weight loss maintenance can improve comorbidities such as insulin resistance, dyslipidemia, hypertension , and sleep apnea, and weight regain can easily inhibit these benefits and even induce adverse diseases again
, weight loss maintenance can improve insulin resistance, dyslipidemia, hypertension , sleep apnea and other comorbidities, and weight rebound can easily inhibit these benefits and even induce adverse diseases again
In this study, researchers aimed to investigate changes in adipocyte size and other The relationship between risk biomarkers and weight regain
.
In this randomized controlled study, 48 overweight/obese participants received a (very) low-calorie diet for weight loss, followed by a 4-week weight stabilization period and a 9-month follow-up period
.
We analyzed anthropometric measures, abdominal subcutaneous adipose tissue adipocyte volume, and plasma metabolic parameters [free fatty acids (FFA), triglycerides (TG), total cholesterol, glucose, insulin, HOMA-IR, IL6, ACE activity, retinol binding protein 4 (RBP4)]
The researchers found that changes in TG, IL6, HOMA-IR, and ACE were significantly positively correlated with weight rebound
.
Multiple linear regression analysis showed that only changes in TG and IL6 remained significantly associated with weight regain and increased body fat mass
Thus, these results suggest that TG and IL6 are related to weight rebound through different mechanisms, and HOMA-IR and adipocyte volume may be indirectly related to weight rebound through changes in plasma TG levels
.
.
Original source:
Original Source: Original Source:Qi Qiao, et al.
Qi Qiao, et al.
Plasma levels of triglycerides and IL6 are associated with weight regain and fat mass expansion.
JCEM.
2022.
https://academic.
oup.
com/jcem/advance-article/doi/10.
1210/clinem/dgac198/ 6562773.
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