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The adverse effects of Roux-en-Y gastric bypass (RYGB) on bones are partly caused by decreased intestinal calcium absorption
.
Prebiotics, such as soluble corn fiber (SCF), can increase colonic calcium absorption in healthy individuals
Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.
Researchers aim to evaluate the effects of SCF on the calcium absorption score (FCA), biochemical parameters and fecal microbiome of the population after RYGB.
.
This randomized, double-blind, placebo-controlled trial was conducted in 20 postmenopausal women who received RYGB an average of 5 years ago
.
The intervention of the study is oral 20g/day of SCF or maltodextrin placebo for a 2-month course of treatment
The average FCA±SD at baseline was low, 5.
5±5.
1%
.
Comparing SCF with placebo, the average (95%CI) change of FCA (+3.
It can be seen that there are no differences between groups in the changes of FCA or calcium stimulating hormone, but the wider confidence interval indicates that the variable effect of SCF may be due to the degree of change in the intestinal microbiome
.
Daily intake of SCF is well tolerated, but it needs to be further verified by larger and longer-term studies
No differences between groups were observed in the changes of FCA or calcitonin, but the wider confidence interval indicated that the variable effect of SCF may be due to the degree of change in the gut microbiome
Original source:
Karin C Wu.
Prebiotic to Improve Calcium Absorption in Postmenopausal Women After Gastric Bypass: A Randomized Controlled Trial in this message