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Although benign, craniofacial tube tumors have the highest incidence of all non-malignant saddle tumors.
not many studies have been made on the weight and metabolic outcomes of patients with adult-developed cranial pharyngophroidoma (AOCP).
, researchers aim to assess postoperative weight and metabolic outcomes in patients with AOCP and determine clinical predictive factors for weight gain, according to a recent study published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.
reviewed AOCP patients who underwent surgery at a single pituitary center between January 2014 and May 2019.
45 AOCP patients were followed for at least 3 months.
follow-up time was 26 months (IQR 10-44).
the study's main outcome indicators were weight/BMI, metabolic merger and pituitary defects recorded in preoperative and final follow-up.
last follow-up, both the body weight and the BMI increased by an average of 3.4 kg (p-0.015) and the BMI increased by an average of 1.15 kg/m2 (p-0.0095).
change in weight was 2.7% (IQR was -1.1%, 8.8%).
obesity rate rose from 37.8 per cent at the baseline to 55.6 per cent in the last follow-up.
third of patients gained about 15 percent of their body weight.
the prevalence of metabolic merging at the time of the last follow-up was no different from the baseline.
the occurrence of pituitary defects increased after surgery, 58% of patients had more than 3 hormone secretion deficiencies.
preoperative BMI was negatively associated with postoperative weight gain, which was still significant after adjusting age, gender, race, tumor and treatment characteristics.
were also higher after surgery in patients who had more than three hormones that were not secreted at the time of their last follow-up.
in this AOCP patient queue, patients with lower BMI during preoperative follow-up gained more weight after surgery.
the results of the study may help doctors better guide patients.
