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Mental symptoms are common in patients with Cushing syndrome (CD) and appear to be partially reversed after treatment.
recently, a research paper was published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, to investigate drug prescriptions associated with the onset of mental symptoms in cd patients before treatment and during long follow-up.
the study, based on the National Longitudinal Registration Centre, researchers identified CD patients diagnosed between 1990 and 2018 from the Swedish Pituitary Register Centre (N-372).
data were collected five years ago, during diagnosis, and during follow-up.
each patient was included in four matching controls.
researchers also performed cross-sectional subgroup analysis on 76 patients with continuous remission.
the study's main outcome indicators came from the Swedish Prescription Drug Registry and the Patient Registry.
5 years ago and when diagnosed, CD patients used antidepressants (OR 2.2 (95% CI 1.3-3.7) and 2.3 (1.6-3.5)), anti-anxiety drugs (2.9 (1.6-) 5.3) and 3.9 (2.3-6.6)) and sleeping pills (2.1 (1.2-3.7) and 3.8 (2.4-5.9)) are more frequent than the controls.
antidepressants (2.4 (1.5-3.9)) and sleeping pills (3.1 (1.9-5.3)) were still elevated during five years of follow-up.
the proportion of CD patients who used antidepressants (26 percent) and sleeping pills (22 percent) did not change at diagnosis and after five years of follow-up, while the number of drugs used for high blood pressure and diabetes decreased.
patients with a median sustained remission of 9.3 years (IQR 8.1-10.4) were more likely to use antidepressants (OR 2.0 (1.1-3.8)) and sleeping pills (2.4 (1.3-4.7)), but the drugs that were not used for hypertension treatment did not change.
result, an increase in psychosophedic use in CD patients has been observed before diagnosis, regardless of the state of remission, indicating that their adverse effects on the patient's mental health persist.
study highlights the importance of early diagnosis of CD and the need for long-term monitoring of mental health.
