JCEM: Relationship between hbA1c levels in pregnant women and adverse delivery outcomes
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Last Update: 2020-06-22
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Source: Internet
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Author: User
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Higher blood sugar levels during pregnancy have been associated with an increased risk of adverse childbirth outcomesEvidence of the relationship between elevated glycifying hemoglobin and adverse birth outcomes in the normal range is limitedIn a recent study published in journal Journal of Clinical Endocrinology and Metabolism, the leading journal in the field of endocrine and metabolic diseases, researchers aimed to explore the relationship between glycated hemoglobin in the normal range and the risk of adverse childbirthdata is derived from the Information System of the Women's and Children's Hospital in Guangdong Province, China, between September 2014 and March 2018The study included 5,658 pregnant women with normal glycifying hemoglobin during pregnancyThe study's main outcome indicators were poor delivery outcomes including premature birth, large babies, and pre-natal babies (LGA)the incidence of preterm birth, large babies and LGA was 4.6% (261/5658), 3.5% (200/5658) and 5.7% (325/5658) of 5,658 subjectsThe multivariate logistic regression model showed a 1% increase in glycated hemoglobin in pregnant women, associated positively associated with an increasein risk of preterm birth (OR 1.58, 95% CI 1.08-2.31), large children (OR 1.70, 95% CI 1.10-2.64) and LGA (OR 1.38, 95% CI 0.98-1.96)The relationship between glycifying hemoglobin and preterm birth was more pronounced in women with pre-pregnancy body mass index (BMI) of 24 kg/m2, it is shown that elevated levels of glycated hemoglobin in the normal range of pregnancy are independent risk factors for premature birth, large babies and the LGAReducing HbAc1 interventions may help prevent adverse birth outcomes
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