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Diabetes has become an important risk factor for death in PATIENTs with COVID-19.
metformin is the most commonly used anti-sugar drug and has been speculated to affect susceptibility and outcomes in PATIENTs with COVID-19 through a variety of mechanisms.
recently, a research paper was published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, to investigate whether metformin use in diabetics was associated with COVID-19 susceptivity and its outcomes.
researchers used a large UK primary care data set to conduct a trend-matching queue study and compared adult patients with type 2 diabetes who currently use metformin and other sugar-lowering drugs (MF-plus) with adult patients currently treated with a sugar-lowering drug (MF-) that does not include metformin.
results were confirmed COVID-19, suspected/confirmed COVID-19 and related mortality.
also conducted a negative controlled outcome (back pain) analysis.
29,558 patients in the MF plus group and 10,271 patients in the MF-group met the inclusion criteria.
in the trend score matching analysis, the adjusted risk ratios for suspected/confirmed COVID-19, confirmed COVID-19 and COVID-19-related mortality were 0.85 (95% CI 0.67, respectively. 1.08), 0.80 (95% CI is 0.49, 1.30) and 0.87 (95% CI is 0.34, 2.20).
factors were not observed in the negative outcome control analysis.
metformin is not associated with COVID-19 risk or COVID-19-related deaths.
, it is safe to continue to use metformin to improve blood sugar control in diabetic patients.