JCEM: Relationship between pregnancy weight gain rate and glucose-insulin metabolism rate in overweight and obese Spanish pregnant women

Background: Pregnancy is a state of progressive insulin resistance, and increased insulin secretion can make up for this state (1)
.
When pancreatic β-cells fail to compensate, hyperglycemia and gestational diabetes (GDM) will occur

.

Hyperglycemia during pregnancy is continuous, even if there is no obvious gestational diabetes, slight impaired blood glucose control is also associated with poor pregnancy and child health outcomes

Methods: This cross-sectional observational study was conducted at the University of California Irvine Clinical Research Center from 2018 to 2020 and included 33 non-diabetic Hispanic pregnant women between 28 and 30 weeks of gestation, with a pre-pregnancy body mass index (BMI) of 25.
0 to 34.
9 kg/m ²
.
Participants ate a standardized liquid mixed meal after fasting overnight

.

²

Results: 60% of women with an average RGWG (0.
36±0.
22 kg/week) were classified as overdose
.
Although rGWG has nothing to do with glucose or insulin AUC or ISI, it accounts for 13.

4% of the variance of ISI-2 after controlling for covariates (maternal age, parity, and pre-pregnancy BMI); for every unit increase in rGWG, ISSI-2 decreases 2.

Figure 1 The median blood glucose (A) and insulin (B) response of the entire study population to a standard diet

Figure 1 The median blood glucose (A) and insulin (B) response of the entire study population to a standard diet

Figure 2 The negative correlation between the weekly weight gain rate during pregnancy and β-cell function, as measured by the insulin secretion sensitivity index (ISSI)-2
.

Figure 2 The negative correlation between the weekly weight gain rate during pregnancy and β-cell function, as measured by the insulin secretion sensitivity index (ISSI)-2
.

Table RGWG predicts fasting blood glucose and β cell function multiple linear regression

Table RGWG predicts fasting blood glucose and β cell function multiple linear regression

Conclusion: Even in the absence of gestational diabetes, RGWG is negatively correlated with β-cell function in the high-risk population of overweight and obese Hispanic pregnant women

.

Even in the absence of gestational diabetes, RGWG is negatively correlated with β-cell function in the high-risk population of overweight and obese Hispanic pregnant women

Lindsay KL, Gyllenhammer LE, Entringer S,et al.

Rate of gestational weight gain and glucose-insulin metabolism among Hispanic pregnant women with overweight and obesity.

Rate of gestational weight gain and glucose-insulin metabolism among Hispanic pregnant women with overweight and obesity.
Leave a message here