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    Home > Active Ingredient News > Endocrine System > JCEM: Significance of lipoprotein (a) levels at birth and early childhood

    JCEM: Significance of lipoprotein (a) levels at birth and early childhood

    • Last Update: 2021-10-20
    • Source: Internet
    • Author: User
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    High Lp (a) is a cardiac vascular genetic risk factors for the disease, 20% of adults have a high level (i.
    e.
    > 42mg / dL,> 88nmol / L)
    .

    Heart blood vessels

    Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.
    Researchers investigated whether the early lipoprotein (a) level measured in cord blood can be used as a representative of neonatal venous blood levels.
    , Whether the level of lipoprotein (a) at birth (ie, cord blood or venous blood) can predict the level in later life, and whether it is related to the level of lipoprotein (a) in early life and parents
    .

    The COMPARE study is a prospective cohort study of newborns (N=450) from Copenhagen, Denmark, including blood sampling from parents
    .


    The researchers measured cord blood (N=402), neonatal venous blood (N=356), infants at 2 months (N=320) and 15 months of follow-up (N=148), and parents (N=705).


    Lipoprotein (a) levels in umbilical cord blood, neonatal vein, 2 and 15-month-old infant vein samples were 2.
    2 (95% CI 1.
    9-2.
    5), 2.
    4 (2.
    0-2.
    7), 4.
    1 (3.
    4-4.
    9) and 14.
    6(11.
    4-17.
    9) mg/dL
    .


    The level of lipoprotein (a) in umbilical cord blood is closely related to the neonatal venous blood level (R2=0.


    It can be seen that the level of lipoprotein (a) is low in the early life, the level of umbilical cord blood lipoprotein (a) can be used as a substitute for the level of neonatal venous blood lipoprotein (a), and the level of lipoprotein (a) at birth is greater than or equal to the 90th hundredth Quantiles can identify newborns with increased risk
    .

    The level of lipoprotein (a) is low in the early life.
    The level of umbilical cord blood lipoprotein (a) can be used as a substitute for the neonatal venous blood lipoprotein (a) level.
    The level of lipoprotein (a) at birth is ≥90th percentile.
    Identify newborns who are at increased risk
    .


    Original source:

    Original source:

    Nina Strandkjær.


    Lipoprotein (a) Levels at Birth and in Early Childhood - The COMPARE Study in this message
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