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Glucose homeostasis is regulated by circadian rhythms through endocrine and intracellular mechanisms.
Evidence from several studies shows that melatonin affects glucose homeostasis
.
Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.
The study aims to evaluate the effects of melatonin on incretin, glucagon-like peptide 1 (GLP-1) and intestinal The effect of gastric inhibitory peptide (GIP) secretion and their effect on β-cell insulin secretion
.
The study combines a human randomized, double-blind, placebo-controlled crossover study with a confirmatory in situ study of intestinal perfusion in rats
.
The researchers conducted 2x2 examinations on 15 healthy male participants: an oral glucose tolerance test (OGTT) on the first day, and a repeated OGTT on the second day, and treated with melatonin and placebo, respectively
In human trials, melatonin treatment resulted in a decrease in GIP secretion compared with placebo (ANOVA p=0.
003).
This effect was also observed in the intestinal tract of perfused rats (ANOVA p=0.
003), in which GLP-1 was secreted It is also affected by arterial infusion of melatonin (ANOVA, p<0.
Melatonin reduces the secretion of GIP during oral glucose in healthy young men, but does not affect insulin secretion
Original source:
Esben Stistrup Lauritzen.
et al.
The effect of melatonin on incretin hormones – results from experimental and randomized clinical studies .
JCEM.
2021.
https://doi.
The effect of melatonin on incretin hormones - results from experimental and randomized clinical studies in this message