JCEM: The effect of vitamin D supplementation on insulin sensitivity and secretion in prediabetes

Vitamin D can regulate the pathway of sugar homeostasis
.

Observational studies have reported that there is a strong and consistent correlation between low blood vitamin D levels and increased risk of type 2 diabetes

Vitamin D diabetes

This study aims to investigate the effects of vitamin D3 supplementation on insulin sensitivity and β-cell function
.

This is a pre-specified secondary analysis of vitamin D and type 2 diabetes (D2d) research
.

In the study, overweight or obese adults at risk of type 2 diabetes were randomized to receive vitamin D3 (4000 IU) or placebo daily for up to 24 months

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Changes in insulin sensitivity and β-cell function in subjects with baseline 25(OH)D<12 ng/mL

The subjects were 60.
5±9.
8 years old on average, and the average BMI was 31.
9±4.
4 kg/m2
.

At the second year, the average serum 25(OH)D level of the vitamin D group increased from 27.

At the second year, the average serum 25(OH)D level of the vitamin D group increased from 27.

In patients with prediabetes who were not selected based on their baseline vitamin D status, continuous vitamin D3 supplementation for 24 months did not improve the OGTT-derived β-cell function index; however, people with very low baseline vitamin D levels could benefit from vitamin D supplementation

Original source:

Rasouli Neda,Brodsky Irwin G,Chatterjee Ranee et al.

Effects of vitamin D supplementation on insulin sensitivity and secretion in prediabetes in this message