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Gestational diabetes (GDM) during pregnancy has negative short-term and long-term effects on mothers and babies
.
Women with gestational diabetes mellitus (GDM) are at higher risk of onset during pregnancy (including the risk of gestational hypertension/preeclampsia and complicated childbirth (including caesarean section)), and are more likely to develop type 2 diabetes (T2D) in the future And cardiovascular disease
Women with gestational diabetes mellitus (GDM) are at higher risk of onset during pregnancy (including the risk of gestational hypertension/preeclampsia and complicated childbirth (including caesarean section)), and are more likely to develop type 2 diabetes (T2D) in the future And cardiovascular disease
GDM is caused by changes in glucose metabolism, which usually start in the second half of pregnancy, and insulin resistance increases to adapt to the growth of the fetus
.
In women without GDM, increased β-cell insulin secretion compensates for insulin resistance to regulate blood sugar levels
Insulin resistance increases to adapt to the growth of the fetus
The rate of weight gain during pregnancy may be a modifiable factor of insufficient β-cell function, and insufficient β-cell function may lead to hyperglycemia and the long-term development of T2D during pregnancy
The findings of Lindsay et al.
provide valuable information for us to understand the glucose metabolism of Hispanic women
.
However, their cross-sectional study did not evaluate the glucose metabolism at the two critical time points before pregnancy and early pregnancy, leaving the problem that GWG has the greatest impact on glucose metabolism during pregnancy
Weight gain in early pregnancy may be a key modifiable risk factor
GDM is a heterogeneous disease composed of several different phenotypes, including insulin-resistant GDM, insulin-deficient GDM, and mixed GDM (characterized by insulin resistance and insulin deficiency)
LeBlanc ES, Hillier TA, The impact of gestational weight gain on glucose and insulin physiology in pregnancy-does timing matter? J Clin Endocrinol Metab 2021 Oct 11
The impact of gestational weight gain on glucose and insulin physiology in pregnancy-does timing matter? Leave a message here
