JCEM: The relationship between maternal testosterone concentration in the third trimester and child's handgrip strength at 5 years of age

Muscular strength, power, and endurance in children were positively associated with factors such as gender, age, puberty, physical activity, bone health, and self-esteem; these muscle parameters were inversely associated with obesity, metabolic risk factors, and later cardiovascular disease in children and adolescents
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A study published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, aimed to investigate the possible association between maternal testosterone concentrations in the second trimester and offspring handgrip strength (HGS) at 5 years of age.

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In a population-based prospective cohort of Odense children, researchers measured total testosterone (TT) and offspring HGS at 5 years of age in 1017 mother-child pairs at 27-28 weeks of gestation
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The FT concentration in the third trimester was 0.
004 (0.
002-0.
007) nmol/L
.

CONCLUSIONS: FT concentrations in late pregnancy were inversely correlated with HGS-assessed muscle strength at 5 years of age in offspring, which may suggest that maternal FT negatively affects offspring muscle strength
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Original source:

Malene Dybdahl, et al.