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Increased concentration of branched chain amino acids (BCAA) is a strong predictor of type 2 diabetes (T2DM)
.
They and heart blood vessels association between the disease (CVD) is unclear, especially among young people
Diabetes, heart blood vessels
Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.
Researchers explored BCAA in a randomized controlled study of normal weight (NW) and obese (OB) youths.
And the role of aromatic amino acids (AAA) in obesity, and their relationship with new CVD biomarkers, and evaluated the response to physical activity-based life>
.
The researchers analyzed young people (OB, n=15 and NW, n=6) matched for age (14-18 years) and Tanner stage (≥IV); 15 OB participants received a 3-month randomized controlled PAL -I
.
The researchers measured the amino acid profile, blood glucose, insulin, lipids, adiponectin, retinol binding protein 4 (RBP4), fibrinogen, high sensitivity c-reactive protein (hs-CRP), Interleukin 6 (IL-6) and 25-hydroxyvitamin-D levels and body composition (DXA)
Branched chain amino acid level
Compared with NW, the concentration of various amino acids such as BCAA and AAA changed in OB participants (P<0.
05)
.
BCAA and AAA are associated with body composition and new biomarkers of CVD, especially inflammatory factors (all p<0.
It can be seen that the new results of the association between BCAA and inflammation and the correlation with non-traditional biomarkers of CVD may be beneficial to the use of BCAA as a CVD biomarker and explain the potential association between obesity, T2DM and CVD
.
.
Original source:
Original source:Ralph G Cosentino.
Branched chain amino acid-inflammation relationship in youth with obesity: A randomized controlled intervention study in this message