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JCEM: Thyroid function and cerebral circulation

 Last Update: 2021-10-20
 Source: Internet
 Author: User

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Whether thyroid dysfunction is related to changes in cerebral circulation in the general population is not yet clear
.

Recently, a research article was published in the Journal of Clinical Endocrinology & Metabolism, an authoritative journal in the field of endocrine and metabolic diseases.

The three sub-cohorts of the Rotterdam study started in 1989, 2000 and 2006 respectively
.

Participants A total of 5142 participants (average age 63.

Between 2005 and 2015, all participants underwent brain magnetic resonance imaging to assess overall brain perfusion (mL blood flow/100mL brain tissue/min)
.

The researchers used the digital images of 3105 participants' stereo fundus color transparencies as microcirculation markers to assess the small arteries and retinal calibers, and used a (non-)linear regression model to analyze the association between TSH, FT4 and cerebral circulation indicators

The level of FT4 (in pmol/L) is associated with an inverted U-shape of whole brain perfusion, so higher and lower levels of FT4 are associated with lower whole brain perfusion compared to moderate levels of FT4
.

High FT4 level (25pmol/L) and moderate FT4 level (FT4=15pmol/L; P nonlinearity=0.

Blood vessel

These results indicate that thyroid dysfunction may cause brain diseases such as stroke or dementia through potentially alterable cerebral circulation
.

Thyroid dysfunction may cause brain diseases such as stroke or dementia through potentially alterable cerebral circulation
.

Stroke

Original source:

Lana Fani.

Thyroid status and brain circulation: The Rotterdam Study in this message

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