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    Home > Active Ingredient News > Endocrine System > JCEM: Vitamin B supplementation in children with type 1 diabetes can reduce homocysteine ​​in early diabetic nephropathy

    JCEM: Vitamin B supplementation in children with type 1 diabetes can reduce homocysteine ​​in early diabetic nephropathy

    • Last Update: 2021-09-03
    • Source: Internet
    • Author: User
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    The main physiological function of B vitamins is to act as a coenzyme and participate in ubiquitous biochemical reactions in the body


    The main physiological function of B vitamins is to act as a coenzyme and participate in ubiquitous biochemical reactions in the body


    Background: Homocysteine ​​levels are elevated in patients with type 1 diabetes (T1DM), which can cause kidney damage


    Background: Homocysteine ​​levels are elevated in patients with type 1 diabetes (T1DM), which can cause kidney damage


    OBJECTIVE: We conducted a randomized controlled trial, in T1DM children patients with oral vitamin B complex as adjuvant treatment of kidney disease, and to assess with kidney disease biological markers homocysteine and cystatin C relationship


    Method: The test involves 80 patients with T1DM have microalbuminuria, although they used the angiotensin converting enzyme inhibitor , aged at 12 is - 18 years, at least with a 5-year duration, glycated hemoglobin (HbAIc) ≤ 8.


     Results: The clinical the baseline and lab data are a good match







    Baseline cystatin C was negatively correlated with vitamin B12 ( rbaseline cystatin C was negatively correlated with vitamin B12 = -0.




    Conclusion: Vitamin B complex can improve blood sugar control and renal function by lowering homocysteine.


    Original source

    Elbarbary NS, Ismail E, Zaki MA, Darwish YW, Ibrahim MZ, El-Hamamsy M.
    Vitamin B complex supplementation as a homocysteine-lowering therapy for early stage diabetic nephropathy in pediatric patients with type 1 diabetes: A randomized controlled trial.
    Clin Nutr .
    2020.
    39(1): 49-56.

    Elbarbary NS, Ismail E, Zaki MA, Darwish YW, Ibrahim MZ, El-Hamamsy M.
    Vitamin B complex supplementation as a homocysteine-lowering therapy for early stage diabetic nephropathy in pediatric patients with type 1 diabetes: A randomized controlled trial.
    Clin Nutr .
    2020.
    39(1): 49-56.


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