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Background: Several lines of evidence may support a role for vitamin D status in SARS-CoV-2 infection
.
First, vitamin D deficiency is a common condition around the world, and serum 25-hydroxyvitamin D (25-OHD) levels are seasonal and geographic
Vitamin D deficiency is a common condition around the world, and serum 25-hydroxyvitamin D (25-OHD) levels are seasonal and geographic
Objective: To assess serum 25-hydroxyvitamin D (25-OHD) levels in hospitalized patients with COVID-19, and to analyze the possible impact of vitamin D levels on disease severity
.
Methods: A retrospective case-control study was performed on 216 COVID-19 patients and 197 normal people
.
The serum 25-OHD levels of the two groups were measured
RESULTS: Of 216 patients, 19 were taking vitamin D supplements and analyzed separately
.
In COVID-19 patients, the mean ± SD of 25-OHD levels was 13.
Table 1 Main characteristics of patients with COVID-19 assessed according to vitamin D deficiency status
Table 1 Main characteristics of patients with COVID-19 assessed according to vitamin D deficiency statusTable 2 Main characteristics of oral and non-oral vitamin D supplementation in patients with COVID-19 on admission
Table 2 Main characteristics of oral and non-oral vitamin D supplementation in patients with COVID-19 on admissionFigure 1 Serum vitamin D levels in hospitalized COVID-19 patients with and without active oral vitamin D supplementation and in population-based control patients, according to sex
.
Gray lines represent males, white lines represent females
Figure 1 Serum vitamin D levels in hospitalized COVID-19 patients with and without active oral vitamin D supplementation and in population-based control patients, according to sex
Figure 2 Comparison of patients with new coronary pneumonia (excluding patients taking vitamin D on admission) and control groups according to different time periods of serum 25OHD levels
.
.
Figure 3 Correlation of serum 25OHD with inflammatory markers (A ferritin, BD-dimer, C C-reactive protein)
.
.
Conclusions: Hospitalized COVID-19 patients had lower levels of 25-OHD than population-based controls, and these patients had a higher prevalence of vitamin D deficiency
.
We did not find any relationship between vitamin D levels or vitamin deficiency and disease severity
Hospitalized COVID-19 patients had lower 25-OHD levels than population-based controls, and these patients had a higher prevalence of vitamin D deficiency
Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection.
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