JCEM: Vitamin D status and risk of death from whole causes and specific causes

Although a negative correlation between vitamin Dstatus and mortality has been reportedin observational studies, the exact pattern of correlation and optimal vitamin D status has not yet been determinedRecently, the authoritative journal journal of endocrine and metabolic diseases published a study aimed at identifying the link between vitamin D status and the risk of death from whole causes and specific causes, and estimating the optimal serum 25-hydroxyvitamin D (25 (OH) Dthe prospective cohort study was based on the UK Biobank and involved 365,530 individuals with ahistory of serum 25 (OH) D at baseline (2006-2010), nocardiovascularvasculardisease (CVD), cancer ordiabetesThe main observations of the study were mortality for whole causes and for specific causes10,175 deaths occurred during the median follow-up period of 8.9 years (with a quadrial pitch of 8.3-9.5), including 1,841 deaths from CVD (18.1%) and 5737 deaths from cancer (56.4%)Multiple analyses revealed a non-linear negative correlation, with a decrease in the risk of death appearing to level off at 25 (OH) D levels of 60 nmol/L for whole causes and CVD deaths, and a reduced risk of cancer death at 45 nmol/LCompared to subjects with concentrations below the threshold of 25 (OH) D, the total mortality rate of high concentration subjects decreased by 17% (0.83, 95% CI was 0.79-0.86), CVD mortality decreased by 23% (HR was 0.77, 95% CI was 0.68-0.86), and cancer mortality decreased by 11% (HR 0.89, 95% CI 0.84-95), higher concentrations of 25 (OH) D were not linearly related to lower risk of all-cause, CVD, and cancer deathThe threshold of 45-60 nmol/L may be an intervention target to reduce the overall risk of early death, which needs to be further identified in large clinical trials