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Weight gain is the main reason for the loss of satisfaction and quality of life in patients with hypothyroidism, and the data on weight changes after thyroidectomy are contradictory.
recently, a study published in Journal of Clinical Endocrinology and Metabolism, an authoritative journal in the field of endocrine and metabolic diseases, aims to provide a systematic review of the literature and a meta-analysis of weight changes after total thyroid excision.
researchers conducted a literature search on PubMed and selected an English-language study published between September 1998 and May 2018 that reported changes in weight after thyroidectomy.
study data were reviewed and compared by three investigators;
used fixed and random effect models for meta-analysis.
study follow-up, gender, and age, the researchers analyzed metagression models of single-variable and multivariable weight changes, and performed exploratory subgroup analysis of surgical fingering.
system evaluation included 17 studies (3,164 patients) with follow-up time of 23.8±23.6 months.
serious heterogeneity was observed in the study.
using random effect models, the overall weight change was estimated to be an increase of 2.13 kg and a 95% CI of 0.95-3.30.
age was negatively related to changes in weight (β -0.238, p.lt;0.001).
in the subgroup analysis, the weight gain was more pronounced in patients with hyperthyroidism with hyperthyroidism at 5.19 kg and 95% CI at 3.21-7.17, compared to thyroid Patients with glandular swelling or malignant tumors were 1.55 kg, 95% CI was 0.82-2.27 and 1.30 kg, and 95% CI was 0.45-2.15.
result, patients undergoing thyroidectomy may experience mild weight gain, especially in younger patients and patients with hyperthyroidism.
forward-looking studies are needed to assess the pathophysiological mechanisms of weight gain after thyroidectomy and to evaluate new treatments to better summarize changes in weight after thyroidectomy.