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JCI Insight: Acute Aerobic Exercise Reveals FAHFA Metabolites That Differentiate Between Overweight and Normal Weight Runners

 Last Update: 2022-04-21
 Source: Internet
 Author: User

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Background: The obesity epidemic and its associated cardiometabolic complications are recognized worldwide as a public health crisis

The obesity epidemic and its associated cardiometabolic complications are recognized worldwide as a public health crisis

Exercise remains a highly effective life>

RESULTS: Post-exercise NWT and OWT metabolic profiles jointly increased circulating acylcarnitines and free fatty acids (FFAs), while inosine and hypoxanthine, intermediates of adenine metabolism, were strongly associated with body fat percentage and VO2max

Figure 1 Study design and untargeted metabolomic analysis pipeline

Figure 2

Figure 3: Exercise-induced metabolic profile in OWT correlates with circulating cytokines

These findings in overweight human participants and healthy controls suggest that exercise-induced changes in FAHFA distinguish normal-weight from overweight individuals and predict VO2 max

Acute aerobic exercise reveals FAHFAs distinguish the metabolomes of overweight and normal weight

runners

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