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    Home > Active Ingredient News > Digestive System Information > JCI Insight: Yale scientists have confirmed that the benefits of intestinal health begin in the womb.

    JCI Insight: Yale scientists have confirmed that the benefits of intestinal health begin in the womb.

    • Last Update: 2020-10-20
    • Source: Internet
    • Author: User
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    It is well known that the effects of the gut microbiome on human health run through life, and the gut, like the brain, is as important and indispensable as the body, so it is also called the second brain.
    a recent study published in JCI Insight, a team from Yale University in the United States revealed the earliest stages of the formation of gut microbiomes, and since then they have been providing benefits to the body.
    symbly microbial implantation through the establishment of an intestinal microbiome is critical to many intestinal functions, including nutritional metabolism, intestinal barrier integrity and immunomodulation.
    is controversial about the presence of a gut microbiome in the fetus, and it is not clear whether there are microbial-derived metabolites in the womb.
    the new study is to determine whether bacterial DNA and microbial-derived metabolites can be detected in human gut samples in the middle of pregnancy.
    In the study, a team led by Dr. Liza Konnikova, an assistant professor of pediatrics and obstetrics, gynecology and reproductive sciences at Yale University, reported a unique fetal metabolomic characteristic that contains a large number of bacterial and host-origin metabolites.
    that the gut microbiome has begun to form in the womb, much earlier than we knew.
    suspect that microbial metabolites detected at this early stage were transferred from the mother to the fetus through the placenta.
    for more than a year, the team has been studying the development of the human gut immune system.
    early studies, they found evidence of mature adaptive immune cells in the womb.
    : "It makes us wonder how these immune cells mature. What's guiding them? "This study provides the first clue.
    scientists studied 31 intestinal samples from three different stages of human development: fetal, infancy, and late childhood.
    surprised them, they found by-products of bacteria in all samples, suggesting that microbial components may have existed before childbirth.
    it's not clear whether the metabolites derived from these bacteria are transferred to the fetus through the placenta, Konnikova thinks it seems possible.
    in fetal samples, they detected large amounts of food metabolites, including vitamins B1 and B5, most likely from the mother's prenatal vitamins.
    Konnikova said the metastasis of maternal microbes to support fetal growth would have important evolutionary value.
    " she says, "Exposure to the by-products of bacteria can give your immune system an education on beneficial bacteria, and there is no inflammatory response when exposed to these bacteria again in inflamed in inflammation."
    Konnikova's team is already conducting a follow-up study to determine whether mothers are passing on this immune support to the next generation.
    same time, Konnikova's team found that fetuses contain powerful bacterial metabolites (a complete set of metabolites), which may indicate the potential for delivering vaccines in the womb and other benefits.
    if the mother provides the bacteria needed to improve the fetus's immunity, there may also be an opportunity to build up her own microbiome to provide better immunity to the growing fetus, Konnikova said.
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