-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Despite the widespread impact of the coronavirus disease 2019 ( COVID-19 ) pandemic worldwide, few reports have assessed the association between bacterial colonization of the upper respiratory tract and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) potential interactions between them
.
Therefore, the role of respiratory bacterial pathogens on SARS-CoV-2 infection and pathogenesis remains poorly understood
COVID-19 infection
Traditionally, upper airway virus-pneumococcal interactions have been thought to increase the risk of secondary pneumococcal pneumonia, especially during seasonal influenza and RSV outbreaks
.
However, the proportion of COVID-19 patients with documented pneumococcal pneumonia based on cultures of blood or sputum samples collected during hospitalization was considerably lower
To investigate the interaction of pneumococcus and SARS-CoV-2 and the impact of pneumococcus on host antiviral immune responses, we longitudinally sampled healthcare workers (HCWs) at high risk of SARS-CoV-2 infection and patients with suspected COVID-19 disease
.
method:
method: method:Here, we investigated the relationship of these two respiratory pathogens in two distinct cohorts: a) healthcare workers with asymptomatic or mildly symptomatic SARS-CoV-2 infection identified by systematic screening and b) hospital admissions Patients with moderate to severe disease presenting
.
We assessed the effect of co-infection on host antibody, cellular, and inflammatory responses to the virus
screening
result:
Result: Result:In both cohorts, pneumococcal colonization was associated with diminished antiviral immune responses, primarily affecting mucosal IgA levels in mildly or asymptomatically infected individuals and cellular memory responses in infected patients
.
Figure 2: Impaired mucosal antibody responses to SARS-CoV-2 in pneumococcal-colonized individuals
Figure 3: Streptococcus pneumoniae colonization is associated with reduced levels of SARS-CoV-2 memory B cells
Figure 4: Patients colonized with S.
pneumoniae lack SARS-CoV-2-specific T-cell responses
.
Figure 5: Different nasal inflammation profiles between healthcare workers and COVID-19 infected patients
.
In the nose, the HCW group showed a lack of upregulation of cytokines that function to promote T and B cell maturation and differentiation
.
In blood, non-colonized patients exhibited increased inflammatory signatures (16/30 cytokine upregulation) compared to Spn-colonized patients (9/30 cytokine upregulation)
in conclusion:
Conclusion: Conclusion:Our findings suggest that S.
pneumoniae impairs host immunity to SARS-CoV-2 and raises the question of whether pneumococcal carriage also enables immune escape of other respiratory viruses and promotes reinfection
.
Despite the observational design, our study has identified pneumococcal colonization as a variable that modulates the host immune response to SARS-CoV-2 infection
.
Impaired acquired immunity against natural SARS-CoV-2 infection may increase susceptibility to subsequent SARS-CoV-2 infection
Original link: https://pubmed.
https://pubmed.
leave a message here