JCI: Uncovering novel molecular mechanisms of the body's defense against cancer progression

March 6, 2022 / Bio Valley BIOON / -- The bone marrow microenvironment can regulate the initiation, proliferation and chemotherapy resistance of acute myeloid leukemia (AML), and increasing research evidence shows that when cancer cells die , the remaining apoptotic debris plays an important role in modulating the immune response and in growth of solid tumors

Cancer cells during cell division

Image credit: National Institutes of Health

Acute myeloid leukemia is a very difficult type of leukemia to treat.

The researchers also discuss the potential implications of the findings for future leukemia treatments

Image source: https:// researchers identified these mechanisms in the bone marrow of leukemia patients and mouse models of acute myeloid leukemia; Dr.

Taken together, the results of this study suggest that the effect of macrophages on apoptotic debris in the bone marrow microenvironment of patients with acute myeloid leukemia may be expected to inhibit tumor progression

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Jamie A.