JCO: Digital Breast Cancer Course Management Based on Electronic Patient-Reported Outcome (ePRO) Monitoring and Automated Management of Intervention Reminders (eRAPID Study)

Breast cancer is one of the common malignant tumors threatening women's health and the leading cause of cancer-related deaths in women worldwide

The Journal of Clinical Oncology, a leading international oncology journal, reported the results of a phase III randomized controlled trial conducted by researchers at the University of Leeds, St.

(Image source: Journal of Clinical Oncology)

research method

The subjects of the study were cancer patients who started chemotherapy, most of them were breast cancer patients, and the rest were gynecological cancer and colorectal cancer patients

eRAPID group: On the basis of routine care, patients were also managed based on the ePAPID system

The eRAPID system combines ePRO symptom reporting with customized clinical algorithms to provide patients with automated, severity-based recommendations to support patients in self-management or contacting the hospital

Main outcome: Symptom control assessed at 6, 12, and 18 weeks (functional assessment of cancer care, physical fitness subscale FACT-PWB)

Among the participants, there were 508 patients (73.

Subgroup analysis found a significant benefit in the non-metastatic group at week 6 (P = 0.

Results showed that real-time monitoring via the ePRO system improved physical health (weeks 6 and 12) and self-efficacy (week 18) in a primarily curative patient population without increasing hospital workload

Research Implications

These findings demonstrate that remote real-time monitoring is feasible in routine cancer care, especially in the context of the COVID-19 pandemic; an alternative digital care model during therapeutic chemotherapy that can help cancer patients with mild to moderate symptoms Improve physical condition, reduce hospital visits, and even improve quality of life and long-term survival

In the future, the digital clinical trial (DCT) model will become more and more mature with continuous exploration

Original source:

Absolom K, Warrington L, Hudson E, Hewison J, Morris C, Holch P, Carter R, Gibson A, Holmes M, Clayton B, Rogers Z, McParland L, Conner M, Glidewell L, Woroncow B, Dawkins B, Dickinson S , Hulme C, Brown J, Velikova G.

Basch E, Leahy AB, Dueck AC.