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JCO: Prognosis of children with adrenocortical carcinoma of different stages treated with various regimens

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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Adrenocortical carcinoma (ACC) is a rare aggressive childhood malignant tumor with unique biological characteristics.

child

A prospective single-arm risk-stratification intervention study published recently in " J Clin Oncol " outlines (1) the prognosis of stage I ACC patients undergoing adrenalectomy alone, (2) adrenalectomy and retroperitoneal lymph nodes The prognosis of dissected stage II patients (complete resection >200 cc or >100 g), (3) the prognosis of stage III or IV patients receiving mitotane and chemotherapy.

J Clin Oncol J Clin Oncol

EFS and OS in patients of different stages

From September 2006 to May 2013, a total of 78 patients (77 eligible, 51 women) were enrolled.

The estimated 5-year event-free survival rates for patients with stage I (24 cases), stage II (15 cases), stage III (24 cases), and stage IV (14 cases) were 86.

In univariate analysis, age, stage, virilization, Cushing’s syndrome or hypertension, germline TP53 status, and the presence of somatic ATRX mutations are associated with prognosis

In summary, the surgical treatment of children with stage I ACC has good results.

Surgical treatment of children with stage I ACC has good results.

Original source:

Rodriguez-Galindo Carlos, Krailo Mark D, Pinto Emilia M et al.

org/10.
1200/JCO.
20.
02871" target="_blank" rel="noopener">Treatment of Pediatric Adrenocortical Carcinoma With Surgery, Retroperitoneal Lymph Node Dissection, and Chemotherapy: The Children's Oncology Group ARAR0332 Protocol in this message

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