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    Home > Active Ingredient News > Antitumor Therapy > JCO: The efficacy of nivolumab combined with ipilimumab in maintenance treatment of advanced small cell lung cancer

    JCO: The efficacy of nivolumab combined with ipilimumab in maintenance treatment of advanced small cell lung cancer

    • Last Update: 2021-03-30
    • Source: Internet
    • Author: User
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    Nivolumab is a fully human anti-PD-1 antibody, and Ipilimumab is a fully human anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) antibody.


    Immunity In patients with melanoma and renal cell carcinoma, the combined treatment of nivolumab + ipilimumab achieved an overall survival (OS) that exceeded the previous standard treatment.


    A previous trial published in the New England Journal of Medicine (NEJM) suggested that patients with non-small cell lung cancer ( NSCLC ) who used nivolumab + ipilimumab had a higher response rate than the nivolumab monotherapy group , Especially in patients whose tumors express PD-L1.


    The response rate of patients with non-small cell lung cancer ( NSCLC ) treated with nivolumab + ipilimumab is higher than that in the nivolumab monotherapy group, especially in patients whose tumors express PD-L1.


    ASCO

    CheckMate 451 is a double-blind phase III trial that evaluates the difference in the efficacy of nivoliyu combined with ipilimumab and nivoliyu monotherapy as a maintenance treatment after first-line chemotherapy for ED-SCLC.


    The participants were randomly assigned (1:1:1) to the combination medication group or single-agent treatment group.


    The primary endpoint of the study was the overall survival (OS) of the nivoliu combined with ipilimumab group compared with placebo.


    Results A total of 834 patients received randomized treatment.


    In general, compared with placebo, patients in the nivouliu combined with ipilimumab treatment group did not significantly prolong OS (HR=0.


    In patients with tumor mutation burden ≥13 mutations/MB, the OS benefit trend of the nivoliu combined with ipilimumab treatment group was observed.


    In patients with tumor mutation burden ≥13 mutations/MB, the OS benefit trend of the nivoliu combined with ipilimumab treatment group was observed.


    For patients with ED-SCLC who did not progress with first-line chemotherapy, maintenance therapy with nivoliyu combined with ipilimumab did not prolong OS.


    references:

    Taofeek K.


    org/doi/full/10.
    1200/JCO.
    20.
    02212" target="_blank" rel="noopener">Nivolumab and Ipilimumab as Maintenance Therapy in Extensive-Disease Small-Cell Lung Cancer: CheckMate 451.
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