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Background: Shenlian Decoction (SL) is composed of Coptis chinensis and ginseng, and berberine and ginsenosides are its main components
Shen Lian Tang (SL) Shen Lian Tang (SL) Coptidis and Panax ginseng both have the effect of mediating glucose metabolism Mediate glucose metabolism
Objective: Intestinal flora disturbance is one of the important factors causing diabetes.
Gut flora disorder Gut flora disorder
METHODS: db/db mice with fasting blood glucose (FBG) higher than 13.
Fasting blood glucose (FBG)
FBG in the tail vein was measured by a blood glucose meter every 4 weeks for 8 consecutive weeks
Fresh Stool Samples Fresh Stool Samples 16S rRNA V3+V4 Region Sequencing 16S rRNA V3+V4 Region Sequencing Metagenomics Metagenomics
Results: Compared with ginseng and coptis, SL decoction had better hypoglycemic effect and β-cell protection effect
Hypoglycemic and β-cell protection hypoglycemic and β-cell protection
KEGG analysis and metagenomic sequencing showed that SL decoction could reduce the abundance of Prevotellaceae , Rikenellaceae and Helicobacteraceae , which were related to lipopolysaccharide biosynthesis , riboflavin , respectively.
Decreased biosynthesis of lipopolysaccharide by Prevotella, Rikenbacteriaceae, Helicobacteraceae , lipopolysaccharide, riboflavin metabolism , up-regulated peroxisomes, up- regulated abundance of Bacteroidaceae, up- regulated abundance of Bacteroidaceae, promoted starch and sucrose metabolism and pentose gluconate conversion
Conclusion: SL decoction has obvious hypoglycemic effect , and its mechanism may be related to the regulation of intestinal flora by up- regulating acidobacter
hypoglycemic effect hypoglycemic effect regulates intestinal flora by up-regulating acidobacter
Source:
Sun, RX, Huang, WJ, Xiao, Y.
Sun, RX, Huang, WJ, Xiao, Y.
, et al.
(2022).
Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice.
Journal of diabetes research , 2022, 7802107.
https://doi.
org/10.
1155/2022/7802107 Journal of diabetes research
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