JEM: Demystifying the molecular mechanism by which platelets help cope with lung inflammation in the body

In addition to hemostasis, platelets can also actively participate in the recruitment of the body's immune cells and the host's defense process, but researchers are not clear about its key role in solving the body's inflammatory process

Recently, a research report titled "Platelets orchestrate the resolution of pulmonary inflammation in mice by T reg cell repositioning and macrophage education" was published in the International Journal of Experimental Medicine.

The researchers said that platelets can cooperate with regulatory T cells and send signals to the body's scavenger cells

In the bacterial inflammatory lung tissue of mice, platelets (red) can interact with regulatory T cells (yellow)

Image source: Jan Rossaint, et al.

In summary, the results of this article show that platelets can cooperate with continuous immune cells to regulate the onset of inflammation and the resolution of inflammation in the later stages

Note: The original text has been deleted

Original source:

Jan Rossaint, Katharina Thomas, Sina Mersmann, et al.