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    Home > Active Ingredient News > Digestive System Information > JGH: Active neutrophil chemotaxis contributes to the anti-TNFα therapeutic effect in inflammatory bowel disease

    JGH: Active neutrophil chemotaxis contributes to the anti-TNFα therapeutic effect in inflammatory bowel disease

    • Last Update: 2021-12-24
    • Source: Internet
    • Author: User
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    TNF α is mainly a cytokine produced by activated mononuclear macrophages and has a variety of biological effects.


    TNF α is mainly a cytokine produced by activated mononuclear macrophages and has a variety of biological effects.


     

    Researchers systematically collected and collated public transcriptome data of IBD patients receiving anti-TNFα therapy


    immunity

     

    The researchers collected 449 cell samples from control, baseline, and primary anti-TNFα treatment failure patients


    statistics

     

    This study confirmed that overactive neutrophil chemotaxis affects the response to anti-TNFα treatment, and IL13RA2 is a potential biomarker for predicting the response to anti-TNFα treatment


    This study confirmed that overactive neutrophil chemotaxis affects the response to anti-TNFα treatment, and IL13RA2 is a potential biomarker for predicting the response to anti-TNFα treatment


    Tung On Yau.


    Hyperactive neutrophil chemotaxis contributes to anti-TNFα treatment resistance in inflammatory bowel disease.


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