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    Home > Active Ingredient News > Digestive System Information > JGH: Cholecystectomy can reduce the risk of cholangiocarcinoma in patients with complex gallstones

    JGH: Cholecystectomy can reduce the risk of cholangiocarcinoma in patients with complex gallstones

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
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    Gallstones are a common disease worldwide
    .
    In the natural population of our country, the incidence of gallstones is about 10%

    .
    Female patients are more common, especially obese women, the ratio of male to female is about 1:2

    .
    Gallstones are one of the pathogenic factors of bile duct (gallbladder) cancer
    .
    According to reports, gallstones are positively correlated with liver and gallbladder cancer

    .
    However, the risk of these cancers in patients with cholecystectomy or complex gallstones is controversial

    .
    This study aims to explore the impact of cholecystectomy on the risk of cholangiocarcinoma (CCA) or hepatocellular carcinoma (HCC) in patients with gallstones and complex gallstone subgroups

    .

    Gallstones are a common disease worldwide
    .
    In the natural population of our country, the incidence of gallstones is about 10%

    .
    Female patients are more common, especially obese women, the ratio of male to female is about 1:2

    .

     

    The researchers used the Korean National Health Insurance database to include gallstone patients (n=958,677) and age- and gender-matched control patients (n=9,586,770)
    .
    Complex gallstones are defined as gallstones associated with acute cholecystitis or acute cholangitis

    .
    Compared with the control group, the researchers evaluated the risk ratio (aHR, 95% CI) of the incidence of CCA and HCC in patients with gallstones undergoing cholecystectomy, and also analyzed the impact of these on patients with complex gallstones

    .

     

    The results of the study showed that compared with the control group, the risk of CCA (1.
    80, 1.
    67-1.
    93) and HCC (1.
    03, 1.
    00-1.
    07) in patients with gallstones was significantly increased

    .
    Compared with patients who did not undergo cholecystectomy, cholecystectomy had the least impact on the risk of CCA (1.
    94, 1.
    76-2.
    14) and HCC (0.
    93, 0.
    87-0.
    99)

    .
    However, the risk of CCA in patients with complex gallstones is significantly increased (5.
    62, 4.
    89-6.
    46), and the risk after cholecystectomy is reduced by 30% (3.
    91, 3.
    43-4.
    46)

    .
    Compared with intrahepatic CCA or Vater's ampullary carcinoma, cholecystectomy has a greater reduction in the risk of extrahepatic CCA

    .
    However, compared with the control group, there was no difference in the risk of HCC between patients with complex gallstones and those who underwent cholecystectomy

    .

     

    Finally, the researchers said: patients with complex gallstones have a significantly increased risk of CCA.
    Cholecystectomy can partially reduce the risk of CCA, but the HCC risk of gallstones or cholecystectomy has little change

    .

    Finally, the researchers said: patients with complex gallstones have a significantly increased risk of CCA.
    Cholecystectomy can partially reduce the risk of CCA, but the HCC risk of gallstones or cholecystectomy has little change

    .

    Original source:

    Hyeong Sik Ahn.
    Et al.
    Cholecystectomy reduces the risk of cholangiocarcinoma in patients with complicated gallstones, but has negligible effect on hepatocellular carcinoma.
    Journal of Gastroenterology and Hepatology.
    2021.

    Cholecystectomy reduces the risk of cholangiocarcinoma in patients with complicated gallstones, but has negligible effect on hepatocellular carcinoma.


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