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    Home > Active Ingredient News > Digestive System Information > JGH: Effects of Elobixibat on serum and fecal bile acid levels and symptoms of constipation in patients with chronic constipation

    JGH: Effects of Elobixibat on serum and fecal bile acid levels and symptoms of constipation in patients with chronic constipation

    • Last Update: 2022-03-05
    • Source: Internet
    • Author: User
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    Elobixibat is an ileal bile acid transporter (IBAT) inhibitor that reduces bile reabsorption, which in turn reduces fat accumulation in the liver
    .


    Improvements in these indicators are important for relieving liver scarring and inflammation, as well as inhibiting fat and blood sugar elevations.


    Elobixibat is an ileal bile acid transporter (IBAT) inhibitor that reduces bile reabsorption, which in turn reduces fat accumulation in the liver


     

    The researchers collected healthy subjects (n = 10) and patients with chronic constipation (n = 19) for a 7-day hospitalization, during which they received meals containing about 60 grams of fat
    .


    Patients with chronic constipation continued to be hospitalized for 7 days with once-daily elobixibat dosing


     

    The findings showed that fecal total and primary bile acids were significantly lower in patients with chronic constipation compared with healthy subjects
    .


    Serum C4 and fibroblast growth factor levels were comparable between groups


     

    Therefore, the study authors concluded that despite comparable C4 levels, fecal bile acid levels were lower in patients with chronic constipation compared with healthy subjects
    .


    Elobixibat treatment increases fecal bile acid excretion and decreases serum bile acid concentrations


    Therefore, the study authors concluded that despite comparable C4 levels, fecal bile acid levels were lower in patients with chronic constipation compared with healthy subjects


     

    Original source:

    Atsushi Nakajima.


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