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JGH: Elevated levels of circulating mitochondrial DNA predict early allograft dysfunction in patients after liver transplantation

 Last Update: 2022-01-21
 Source: Internet
 Author: User

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Analysis of circulating mitochondrial DNA (cmtDNA) has received attention because of its potential to be a clinically useful indicator of tissue damage and disease burden in several diseases

The researchers collected 21 patients who underwent liver transplantation (LT) at Austin Hospital in Melbourne between September 2019 and February 2020

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The results of this study found that the incidence of postoperative complications in LT patients was 47.

Figure: Circulating mitochondrial DNA levels and differences in different liver transplant patients

This study demonstrates that early release of plasma cmtDNA is closely related to hepatocyte damage; however, the late surge of cmtDNA in EAD patients does not appear to be associated with hepatocyte damage

Osamu Yoshino.

Elevated levels of circulating mitochondrial DNA predict early allograft dysfunction in patients following liver transplantation.

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