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    Home > Active Ingredient News > Digestive System Information > JGH: Omega-3 fatty acid emulsion can safely and effectively reduce endotoxemia and sepsis in acute chronic liver failure

    JGH: Omega-3 fatty acid emulsion can safely and effectively reduce endotoxemia and sepsis in acute chronic liver failure

    • Last Update: 2021-08-03
    • Source: Internet
    • Author: User
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    Acute chronic liver failure (ACLF) is an acute condition with high morbidity and mortality
    .
    Even without systemic inflammatory response syndrome (SIRS), the 28-day mortality rate can still be as high as 6-18%


    .


    Acute chronic liver failure (ACLF) is an acute condition with high morbidity and mortality


     

    In this study, 90 ACLF patients were randomly assigned to three groups: A: did not receive lipid emulsion, B: received omega-6 fatty acids, and C: received omega-3 fatty acids


    .


    immunity

     

    In ACLF patients treated with omega-3 fatty acids, serum endotoxin levels were suppressed by 22%
    .
    And A: no lipid emulsion and B: patients who received omega-6 fatty acids increased endotoxin by 4% and 12%, respectively (P<0.


    001)


    + +

     

    This study confirmed that Omega-3 FA can safely and effectively reduce systemic inflammation, endotoxemia and sepsis in ACLF patients
    .
    These lipid emulsions can also be considered as an effective source of immunonutrition for such patients


    .


    This study confirmed that Omega-3 FA can safely and effectively reduce systemic inflammation, endotoxemia and sepsis in ACLF patients


     

    Original source:

    Anand V Kulkarni.


    Et al.


    Omega-3 fatty acid lipid emulsions are safe and effective in reducing endotoxemia and sepsis in acute-on-chronic liver failure: An open-label randomized controlled trial.
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