JGH Open: Relationship between intestinal flora and obesity

Background and objective: The composition of the human gut microbiome is associated with metabolic abnormalities, such as obesity, diabetes and insulin resistanceThe purpose of this study was to assess the effects of race, central obesity and dietary components on the potential effects of the human gut microbiomemethod: This study included a total of 35 subjects from China (n s 14), Malaysia (n s 10) and India (n s 11)The median age is 39 years (range: 22-70 years old), and all patients provide stool samples for intestinal microbiome analysis by using 16S rRNA sequencing and completing the diet questionnaireAnalysis of a group of biomarkers in serum samples (leukin-6, tumor necrosis factor alpha, lipolyinin, lysis edited cell keratin 18, lipopolysaccharide binding proteins and, deformed cells)Central obesity is defined by the threshold of waist circumference in Asiansresults: there was no significant difference in bacterial diversity in race and moderate obesity, and there was no association between inflammatory cytokine levels and obesityThe relative abundance of Anaerofilum (P - 0.02), Gemellaceae (P - 0.02), Streptococcus (P - 0.03), and Rikenellaceae (P - 0.04) decreased significantly in the obese groupFrom the coordinate analysis, the effects of fiber and fat/saturated fat intake are contrasted, and obese people tend to consume fatconclusion: Studies have shown differences in the gut microbiome of obese individualsThe content of certain bacterial groups in the central obesity population was lowFiber and fat/saturated fat diets are key determinants of central obesity