Ji Guangju's research group revealed for the first time the exosome omics characteristics of human embryonic stem cells and induced pluripotent stem cells

Stem cell transplantation is one of the most promising methods in regenerative medicine, offering hope

Stem cell-derived exosomes are extracellular vesicles secreted by stem cells that contain many biologically active substances, such as proteins, lipids and nucleic acids, and are carriers of intercellular signaling, which can replace stem cells to perform biological processes

At present, the components of exosomes (MSC-Exos) derived from human mesenchymal stem cells have been elucidated, but the biological properties of human embryonic stem cell exosomes (hESC-Exos) and human inducible pluripotent stem cell exosomes (hiPSC-Exos) have not been studied

Protein components and miRNA components in three human stem cell exosomes

The exosome components of three stem cell sources participated in the regulation of fine biological processes, and the comparative analysis found that hESC-Exos has significant advantages in regulating development, metabolism, anti-aging, etc.

Ji Guangju, a researcher at the Institute of Biophysics of the Chinese Academy of Sciences, is the corresponding author

Article link: https://stemcellres.

(Contributed by: Ji Guangju Research Group)