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COVID-19 , caused by SARS-CoV-2 , poses an unprecedented threat to global public health , especially the newly emerged Omicron mutant strains are widely circulating around the world, continuously giving neutralizing antibodies and vaccines R&D brings new challenges
Recently, Ji Xiaoyun's research group from the State Key Laboratory of Medical Biotechnology, Nanjing University, Yang Haitao, a researcher at the Institute of Immunochemistry, ShanghaiTech University / Professor of Tsinghua University, a distinguished professor at the ShanghaiTech University Institute of Immunochemistry, and Academician Rao Zihe's research group and Chongqing Medical University Huang Ailong / Jin Aishun's research group used cryo-electron microscopy single particle technology to analyze the high-resolution structure of Omicron mutant Spike protein bound to receptors and antibodies, and elucidated from the perspective of structural biology that Omicron mutant strains escape most of the existing neutralization Antibodies, while retaining the molecular mechanism of effective interaction with the receptor ACE2 , provide new ideas for the design and development of broadly neutralizing antibodies
The research team first obtained the cryo-EM structure of the Omicron Spike-ACE2 complex with a resolution of 2.
The research team then analyzed the structural information of a series of antibody drugs that have been used as a single drug or combination therapy for new coronary pneumonia
The research team further analyzed the cryo-electron microscope structure of the complex of the neutralizing antibody 510A5 and the Spike protein of the three strains of WT , Delta and Omicron , respectively .
In conclusion, this study revealed the molecular mechanism of the interaction between Omicron and ACE2 and escape of neutralizing antibodies, which is currently the most concerned SARS- CoV -2 mutant strain .
Key words: new coronavirus; Omicron; neutralizing antibody; cryo-electron microscopy; immune escape
Article link: https://doi.
