-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
- Cosmetic Ingredient
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Recently, Jiang Xingyu's research group from the Department of Biomedical Engineering, Southern University of Science and Technology, in cooperation with Liu Ye's research group from the Institute of Medical Biology, Chinese Academy of Medical Sciences, published a research paper entitled: Two dimensional nanosheets as immunoregulator improve HIV vaccine efficacy in the journal Chemical Science
.
This study reports a two-dimensional nanosheet as an immunomodulator to improve HIV vaccine efficacy
.
Two-dimensional materials show great potential in drug loading and delivery due to their morphological diversity and porous structure.
However, it is difficult to synthesize planar materials with immunomodulatory functions due to the challenge of introducing immunomodulatory modules.
Development of two-dimensional materials as immunomodulators
.
However, rare earth element-based complexes have shown their unique macrophage-modulating effects
.
In this study, researchers designed and synthesized a new type of 2D erbium-dysprosium nanosheets (2D NSs) with good water solubility (Fig.
1)
.
As an immunomodulator, this nanosheet can target lymph nodes, activate macrophages, and significantly enhance the humoral and cellular immune responses of HIV vaccine in mice (Fig.
2)
.
Analysis of transcriptomic results further revealed that six key molecules (Msr1, Ccr2, Serpinb9, Klrk1, Klrd1, Klrc1) were closely related to 2D NSs-mediated immune regulation in vivo (Fig.
3)
.
Figure 1-2D NS synthesis and characterization Figure 2-2 The role of D NSs in modulating immune responses to HIV DNA vaccines Figure 3 - Transcriptome analysis of mice treated with HIV vaccine alone or HIV vaccine + 2D NSs These results are indicative of this immune modulation The mechanism of the agent provides new insights and can better guide us to optimize the design of other 2D materials with immunomodulatory effects
.
This work is the first to realize the design and proof-of-concept of immunomodulatory 2D NSs, which greatly broadens the options for immune-based prevention and treatment such as infectious disease vaccination and tumor immunotherapy
.
SUSTech is the first unit of the thesis
.
This work has been supported by the National Natural Science Foundation of China, the National Key R&D Program, the Chinese Academy of Sciences, the Tencent Fund XPLORER Award, the Yunnan Provincial Health Commission's Medical Leading Talent Program, the Yunnan Provincial Young and Middle-aged Academic Technology Leader Program, and the Yunnan Provincial Basic Research Program.
support
.
Paper link: https://pubs.
rsc.
org/en/content/articlelanding/2022/SC/D1SC04044H Open for reprinting, welcome to forward to Moments and WeChat groups
.
This study reports a two-dimensional nanosheet as an immunomodulator to improve HIV vaccine efficacy
.
Two-dimensional materials show great potential in drug loading and delivery due to their morphological diversity and porous structure.
However, it is difficult to synthesize planar materials with immunomodulatory functions due to the challenge of introducing immunomodulatory modules.
Development of two-dimensional materials as immunomodulators
.
However, rare earth element-based complexes have shown their unique macrophage-modulating effects
.
In this study, researchers designed and synthesized a new type of 2D erbium-dysprosium nanosheets (2D NSs) with good water solubility (Fig.
1)
.
As an immunomodulator, this nanosheet can target lymph nodes, activate macrophages, and significantly enhance the humoral and cellular immune responses of HIV vaccine in mice (Fig.
2)
.
Analysis of transcriptomic results further revealed that six key molecules (Msr1, Ccr2, Serpinb9, Klrk1, Klrd1, Klrc1) were closely related to 2D NSs-mediated immune regulation in vivo (Fig.
3)
.
Figure 1-2D NS synthesis and characterization Figure 2-2 The role of D NSs in modulating immune responses to HIV DNA vaccines Figure 3 - Transcriptome analysis of mice treated with HIV vaccine alone or HIV vaccine + 2D NSs These results are indicative of this immune modulation The mechanism of the agent provides new insights and can better guide us to optimize the design of other 2D materials with immunomodulatory effects
.
This work is the first to realize the design and proof-of-concept of immunomodulatory 2D NSs, which greatly broadens the options for immune-based prevention and treatment such as infectious disease vaccination and tumor immunotherapy
.
SUSTech is the first unit of the thesis
.
This work has been supported by the National Natural Science Foundation of China, the National Key R&D Program, the Chinese Academy of Sciences, the Tencent Fund XPLORER Award, the Yunnan Provincial Health Commission's Medical Leading Talent Program, the Yunnan Provincial Young and Middle-aged Academic Technology Leader Program, and the Yunnan Provincial Basic Research Program.
support
.
Paper link: https://pubs.
rsc.
org/en/content/articlelanding/2022/SC/D1SC04044H Open for reprinting, welcome to forward to Moments and WeChat groups
