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Proton pump inhibitors (PPI) are commonly used clinically.
Proton pump inhibitors (PPI) are commonly used clinically.
Therefore, a research team from Australia published a study in the Journal of The National Comprehensive Cancer Network (JNCCN) to evaluate the relationship between PPI and fluorouracil treatment-based advanced colorectal cancer survival.
Therefore, a research team from Australia published a study in the Journal of The National Comprehensive Cancer Network (JNCCN) to evaluate the relationship between PPI and fluorouracil treatment-based advanced colorectal cancer survival.
The study is mainly a secondary analysis of randomized controlled studies.
The study is mainly a secondary analysis of randomized controlled studies.
Research data shows that PPI use is associated with poorer OS in colorectal cancer patients (pooled HR, 1.
Similarly, PPI use is associated with poorer PFS in patients with colorectal cancer (overall pooledHR, 1.
Similarly, PPI use is associated with poorer PFS in patients with colorectal cancer (overall pooledHR, 1.
The subgroup analysis found that the survival relationship of PPI use in each treatment subgroup was similar to that of the overall population.
The subgroup analysis found that the survival relationship of PPI use in each treatment subgroup was similar to that of the overall population.
In summary, the use of PPI is related to the poor prognosis of patients with advanced colorectal cancer treated with fluorouracil.
In summary, the use of PPI is related to the poor prognosis of patients with advanced colorectal cancer treated with fluorouracil.
Original source:
Ganessan Kichenadasse, MBBS, FRACP, John O.
Miners, et al.
Proton Pump Inhibitors and Survival in Patients With Colorectal Cancer Receiving Fluoropyrimidine-Based Chemotherapy.
JNCCN.
Online Publication Date: 05 May 2021.
DOI: https://doi.
org /10.
6004/jnccn.
2020.
7670.
Miners, et al.
Proton Pump Inhibitors and Survival in Patients With Colorectal Cancer Receiving Fluoropyrimidine-Based Chemotherapy.
JNCCN.
Online Publication Date: 05 May 2021.
DOI: https://doi.
org /10.
6004/jnccn.
2020.
7670.
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