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Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) has become a common method to improve Parkinson's disease (PD) symptoms (such as resting tremor and limb stiffness), and medical treatment is not effective for these symptoms
Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) has become a common method to improve Parkinson's disease (PD) symptoms (such as resting tremor and limb stiffness), and medical treatment is not effective for these symptoms
Previous studies have found that low-frequency stimulation (60–80 Hz) can improve motor symptoms (such as postural stability) without significant adverse effects on the management of limb tremor
Previous studies have found that low-frequency stimulation (60–80 Hz) can improve motor symptoms (such as postural stability) without significant adverse effects on the management of limb tremor
In this study, a double-blind random crossover design was used to study the effect of low-frequency STN-DBS on the objective measurement of gait rhythm in patients with Parkinson's disease
During the high-frequency and low-frequency STN-DBS and during the withdrawal period, participants completed the assessment of the severity of symptoms and walking
During the high-frequency and low-frequency STN-DBS and during the withdrawal period, participants completed the assessment of the severity of symptoms and walking
Three-axis accelerometer position
Three-axis accelerometer position31 postoperative STN-DBS PD patients participated in the study
31 postoperative STN-DBS PD patients participated in the study
Participating patients
Participating patientsThe analysis of the linear mixed model that controls walking speed shows that during the gait test, stimulation (low frequency and high frequency) has a significant main effect on the ML and VT rhythm of the trunk
The analysis of the linear mixed model that controls walking speed shows that during the gait test, stimulation (low frequency and high frequency) has a significant main effect on the ML and VT rhythm of the trunk
Stimulation parameters and clinical results under high frequency stimulation (HFS) and low frequency stimulation (LFS)
There is no significant difference in walking speed, stride frequency, stride time or stride time variability under high frequency and low frequency conditions
For those patients who could or could not complete low-frequency STN-DBS, there was no difference in age, course of disease, time after surgery, or electrode location
However, for patients who have experienced severe tremor before surgery, the perceived benefit of this therapy may be reduced because the lower frequency may cause these symptoms to reappear
Conway, ZJ, Silburn, PA, Perera, T.
et al.
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