JNNP: A review of cerebral cavernous malformations, a comparison of treatments

Cavernous malformations (CMs) are dilated blood vessels with a typical mulberry-like appearance that occur in veno-capillaries without interfering with brain parenchyma, muscle, or elastic tissue
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According to the latest International Society for the Study of Hemangioma (ISSVA) classification of vascular abnormalities, CMs are defined as slow-flow venous malformations

The meta-analysis was performed to unify the results of all possible treatment regimens, clarify their efficacy, and specify factors associated with the dynamic behavior of CCMs

PubMed, Cochrane Library, Science Direct, ISI Web of Science, Embase and other sources were searched to identify cohort studies published between 1990 and 2020 on the treatment of CCMs
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Preferred reporting item following guidelines for systematic reviews and meta-analyses; the Newcastle-Ottawa scale was used to assess risk of bias and limitations were assessed based on selection/outcome bias

Assess risk factors for poor treatment outcomes

Efficacy and mortality/mortality for each treatment

During the follow-up of 41,098 people, a total of 100 cohorts were analyzed, of which 8,994 patients were treated with CCMs
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Effectiveness in ensuring bleeding prevention was 97% in surgery, 86% in radiosurgery, and 77% in conservative management

During the follow-up of 41,098 people, a total of 100 cohorts were analyzed, of which 8,994 patients were treated with CCMs

Post-treatment bleeding rates in radiosurgery, association with patients, and study characteristics

Surgery is usually considered first-line treatment
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Surgical intervention may be considered in patients with a history of two or more hemorrhages, neurological deficits, or uncontrolled epilepsy, based on long-term accepted thresholds

Surgery is usually considered first-line treatment

BubenikovaA ,SkalickyP ,Benes JrV , et al Overview of cerebral cavernous malformations: comparison of treatment approaches Journal of Neurology, Neurosurgery & PsychiatryPublished Online First:10 March 2022.

BubenikovaA ,SkalickyP ,Benes Jr  V Bubenikova  ABubenikova Skalicky  PSkalicky Benes Jr  VBenes Jr, et al Overview of cerebral cavernous malformations: comparison of treatment approaches Overview of cerebral cavernous malformations: comparison of treatment approachesJournal of Neurology, Neurosurgery & Psychiatry  Published Online First:  10 March 2022.

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