JNNP: Association of Adverse Childhood Experiences with Multiple Sclerosis

Traumatic and stressful life events are associated with an increased risk of autoimmune disease

Traumatic and stressful life events are associated with an increased risk of autoimmune disease

Some of the most consistent environmental risk factors for MS, including low vitamin D levels, low sunlight exposure, Barr virus infection, and obesity, appear to be critical for susceptibility to MS during childhood, especially adolescence

A nationwide prospective cohort study was conducted

A nationwide prospective cohort study was conducted

The primary outcome of the study was the development of MS

History of adverse childhood experiences before age 18 was defined by four abuse items in the 30-week gestation questionnaire; humiliation ("Is someone systematically trying to subdue, demean, or humiliate you over a long period of time?"), threat ("Is someone threatened to harm you?" you or someone close to you?”), physical abuse (“Have you been physically abused?”), and sexual abuse (“Have you been forced to do sexual acts?”)

Incidence and hours of multiple sclerosis in women abused in childhood

Incidence and hours of multiple sclerosis in women abused in childhood

 Including 77997 people in our study, a total of 101926 women from the MoBa cohort (mean follow-up 13 years, IQR 11-15)

 Including 77997 people in our study, a total of 101926 women from the MoBa cohort (mean follow-up 13 years, IQR 11-15)

This is the first comprehensive prospective study evaluating the association between adverse childhood events and subsequent MS

 

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