JNNP: Cerebral-cortical-synth atrophy in C9orf72 gene carriers in genetic frontal temporal lobe dementia is associated with abnormal pain perception.

Frontal temporal lobe dementia (FTD) is a complex neurodegenerative disease that covers a range of symptoms.
behavioral disorders, language dysfunction, cognitive impairment and movement disorders combine to form typical symptoms of FTD, but many other symptoms are also reported to be often overlooked, including changes in pain.
45 percent of patients in the study reported pain, especially in patients with temporal lobe variants, and found pain in up to 55 percent of FTD patients.
.
recent study described an 8/15 (67%) change in the response to pain in FTD patients.
behavioral variability FTD (8/11 (72%) in bvFTD with semantic dementia (SD) and 2/5 (40%) with non-fluent adaffle (PNFA), a less reactive decrease was more typical in bvFTD, although only 6 patients were studied, but this study was the first to find a special association with the C9orf72 gene mutation.
, the authors set out to explore the presence of the condition in a larger population.
patients with hereditary FTD (GENFI) studied the frequency and neural correlation of refratic changes to pain during and during symptoms.
: The study included 533 participants from 22 centres.
of these participants, 462 abnormal pain perception data from GENFI's core clinical assessment: 281 mutant carriers (104 C9orf72, 128 GRN, 49 MAPT) were classified as symptomatic or symptomatic, and 181 mutation-negative controls.
note that there was no difference in severity between the symptomatic C9orf72, GRN and MAPT groups, as measured by the FLD-CDR sum score.
the changes in pain response (mitigation or exacerbation) were assessed through clinical questionnaires, patients were interviewed semi-structuredly, modeled on a clinical dementia score (CDR) scale, with a severity of 0 to 3:0 , 0.0 5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
: Changes in pain perception are characteristic of C9orf7 carriers in GENFI patients and develop after the transition to symptoms in clinical symptoms.
no difference between these changes and control groups with GRN and MAPT mutations and were not seen before symptoms occurred.
neurocorrrelevant factors associated with changes in pain in carriers of C9orf72 mutations are the back of the pasum, synth and cer cerebrocephaly, as well as the forekin and cortical corticals.
The study confirmed previous reports by Fletcher et al. in six people with symptoms of C9orf72 mutation, indicating that the condition was present in about one-third of genFI patients with symptom carriers, but not as high as in the control group.
a large number of symptoms before carriers.
understanding of the specific genetic association of this symptom will improve its recognition in clinical practice: .
has previously been reported to be associated with double-sided mascumen atrophy, although the combination of pain and temperature changes was studied in the study.
is a defined pain area that involves emotional and sensory signal processing, incoming nerves passing pain information through the outer cerum nucleus to the somatic cortical layer and island."
also found that changes in pain perception were associated with other brain regions.
symposomes are associated with the pasal and cortical layers and are thought to be likely to integrate movement, cognition, autonomy and emotional responses to pain through the cerebral-cortical-symposome network.
original link: Convery RS, Bocchetta M, Greaves CV, et al Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI Cohort Journal of Neurology, Neurosurgery and Psygy Published Online First: 05 August 2020. doi: 10.1136/jnnp-2020-323279MedSci Original Source: MedSci Original !-- Content Presentation End - !-- Judge Whether or not to log in.