Obsessive compulsive disorder (OCD) is the main cause of disability in Western countries and a factor that seriously affects the quality of life.
about 10% of patients with severe obsessive compulsive disorder require innovative medical treatments such as deep brain stimulation (DBS).
possible targets, the non-motoric hypothyroidism (STN) is a key node in the substrate neural circuit, closely linked to the marginal cortical region associated with obsessive compulsive disorder (OCD).
method: The effects of chronic non-motor stN-DBS treatment in 19 patients with resoccurring obsessive compulsive disorder (OCD) were analyzed by using forward-looking, observational, single-center, open cohort study method.
the severity of obsessive-compulsive disorder was assessed using the Yale and Brown obsessive-compulsive scales (YBOCS).
YBOCS scores compared with baselines for 6, 12, and 24 months after surgery.
respondents were determined by the YBOCS score improvement of 35%.
Global Assessment Function (GAF) scale is used to assess the impact of improvements.
results: 24 months of follow-up, YBOCS score increased from 33.3±3.5 to 15.8±9.1, an increase of 53.4% (95% CI 11.2-20.4; p.lt;0.0001).
14 of the 19 patients were considered effective, 5 of the 19 cases improved by more than 75% and 10 cases by more than 50%.
GAF rating increased from 34.1±3.9 to 66.4±18.8 (95% CI 56.7-76.1; p-0.0003), an increase of 92%.
most common adverse events include transient anxiety and mild anxiety.
: Non-motor STN chronic DBS is an effective and relatively safe method for treating severe obsessive compulsive disorder, which is resistant to conventional treatment.
Chabardes S, Krack P, Piallat B, et al Deep brain stimulation of the subthalamic nucleus in obsessive-compulsives disorders: long-term follow-up of an open, Prospective, observational cohort Journal of Neurology, Neurosurgery and Psimsy Published Online First: 08 October 2020. doi: 10.1136/jnnp-2020-323421MedSci Original Source: MedSci Original Copyright Statement: All noted on this website "Source: Mets Medicine" or "Source: MedSci Original." "The copyrights to the text, images and audio-visual materials shall be owned by Metz Medicine and shall not be reproduced by any media, website or individual without authorization, and shall be reproduced with the words "Source: Metz Medicine".
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