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    Home > Active Ingredient News > Study of Nervous System > JNNP: Gender differences in phenotypes of Lewy bodies in pathologically defined dementia

    JNNP: Gender differences in phenotypes of Lewy bodies in pathologically defined dementia

    • Last Update: 2021-03-21
    • Source: Internet
    • Author: User
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    Lewy body dementia (DLB) is the second most common neurodegenerative dementia, accounting for about 5% of Alzheimer's patients.
    Although clinical criteria for DLB are available, the
    diagnostic accuracy is still not ideal, partly because of the high degree of clinical heterogeneity.
    An important factor affecting clinical heterogeneity is the common pathology of Alzheimer's disease (AD), which is usually clinically observed together with the pathology of primary Lewy body (LB).
    The existence of this pathology is associated with AD-like cognitive impairment and is less likely to exhibit core DLB features (such as visual hallucinations).
    Therefore, the current diagnostic criteria for DLB require that when determining the possibility of pathological findings, neuropathological assessment of LB and AD pathology has a typical DLB phenotype.

    diagnosis

    Therefore, in order to study whether pure LB pathology is related to different clinical phenotypes of women and men, therefore, in order to study whether pure LB pathology is related to different clinical phenotypes of women and men,infection).
    Participants who were clinically diagnosed with Parkinson's disease (PD) were excluded to avoid the impact of gender differences in PD.
    The inclusion and exclusion criteria provided a sample of 55 women and 156 men from 29 AD research centers in the past and present of NACC.
    Considering that pure LB pathology is more common in men than women, 56 men in the initial sample accounted for the majority.
    The first set of analyses was performed in this initial sample to avoid selection bias.
    Subsequently, the analysis is performed in a sub-sample matching gender and other inequality variables.
    The initial sample includes age, education level, and Braak tau period (male and female n=55).
    Consensus Although Lewy bodies have similar underlying pathologies, women are unlikely to exhibit the core characteristics of DLB.
    Bayram  ECoughlin  DGBanks  SJ Bayram  E Bayram Coughlin  DG Coughlin Banks  SJ Banks , et al bmj.
    com/content/early/2021/02/08/jnnp-2020-325668" target="_blank" rel="noopener">Sex differences for phenotype in pathologically defined dementia with Lewy bodies Journal of Neurology, Neurosurgery & Psychiatry  Published Online First:  09 February 2021.
     
    Published Online First: doi:  10.
    1136/jnnp-2020-325668
    doi:

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