Lewy body dementia (DLB) is the second most common neurodegenerative dementia, accounting for about 5% of Alzheimer's patients.
Although clinical criteria for DLB are available, the diagnostic accuracy is still not ideal, partly because of the high degree of clinical heterogeneity.
An important factor affecting clinical heterogeneity is the common pathology of Alzheimer's disease (AD), which is usually clinically observed together with the pathology of primary Lewy body (LB).
The existence of this pathology is associated with AD-like cognitive impairment and is less likely to exhibit core DLB features (such as visual hallucinations).
Therefore, the current diagnostic criteria for DLB require that when determining the possibility of pathological findings, neuropathological assessment of LB and AD pathology has a typical DLB phenotype.
Participants who were clinically diagnosed with Parkinson's disease (PD) were excluded to avoid the impact of gender differences in PD.
The inclusion and exclusion criteria provided a sample of 55 women and 156 men from 29 AD research centers in the past and present of NACC.
Considering that pure LB pathology is more common in men than women, 56 men in the initial sample accounted for the majority.
The first set of analyses was performed in this initial sample to avoid selection bias.
Subsequently, the analysis is performed in a sub-sample matching gender and other inequality variables.
The initial sample includes age, education level, and Braak tau period (male and female n=55).
Bayram E , Coughlin DG , Banks SJ Bayram E Bayram Coughlin DG Coughlin Banks SJ Banks , et al bmj.
com/content/early/2021/02/08/jnnp-2020-325668" target="_blank" rel="noopener">Sex differences for phenotype in pathologically defined dementia with Lewy bodies Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 09 February 2021.
Published Online First: doi: 10.
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