JNNP: Gray matter atrophy in multiple brain regions can be used as a predictor of the development of dementia

Brain atrophy is one of the pathomorphological characteristics of dementia

Other studies have shown that brain atrophy occurs before cognitive impairment becomes obvious

Several population-based prospective studies have examined the relationship between specific brain regions (such as the hippocampus) and global brain atrophy and the risk of dementia

Therefore, it would be beneficial to clarify the specific brain regions related to the development of dementia in order to improve the risk assessment of the onset of dementia in the future

In addition, this paper also studied the influence of gray matter atrophy in dementia-related brain regions on the ability to predict the onset of dementia in the future

In the Hisayama study, this is a population-based longitudinal study of cerebral cardiovascular diseases.

TBV to ICV ratio of total brain volume at baseline

Participants were followed up for a median of 5.

Participants were followed up for a median of 5.

The total number of gray matter atrophy areas in the four dementia-related brain areas

During the follow-up period, 113 participants developed all-cause dementia, of which 83 had Alzheimer's disease (AD)

113 participants suffered from all-cause dementia, and 83 of them suffered from Alzheimer's disease (AD)

Even after the adjustment of TBV/ICV, the decrease of GMV/TBV levels in the medial temporal lobe, insula, hippocampus and amygdala is still closely related to the risk of dementia

NakazawaT ,OharaT ,HirabayashiN Nakazawa  TNakazawa Ohara  TOhara Hirabayashi  NHirabayashi, et alMultiple-region grey matter atrophy as a predictor for the development of dementia in a community: the Hisayama StudyJournal of Neurology, Neurosurgery & Psychiatry  Published Online First:  20 October 2021.

Leave a message here