JNNP: High-density lipoprotein may reduce the risk of frostbite

Except for a few single-gene variants that account for less than 15% of cases, the exact factors that underpin the development of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) remain unclear

Many epidemiological studies have considered the role of metabolic factors in the development of ALS

Mendelian randomization studies also provide some evidence of a causal relationship between lipid biomarker levels and ALS

Most epidemiological studies of ALS are based on case-control studies.

In this way, Alexander G Thompson and others of the University of Oxford used data from the UK biobank to explore the relationship between metabolic factors, including lipid and carbohydrate metabolism markers in the blood, physical exercise and BMI, and the subsequent development of ALS.

Higher total cholesterol: High-density lipoprotein is associated with an increased risk of ALS ( HR 1.

In a model that combines multiple metabolic markers, in addition to a higher risk of high-density lipoprotein or lipoprotein A, higher low-density lipoprotein or lipoprotein B is associated with an increased risk of ALS

Coronary artery disease, cerebrovascular disease and aging are also associated with an increased risk of ALS

They found that the association of HDL, apoA1, and LDL levels with the risk of ALS contributes to growing evidence that pre-disease metabolic conditions may play a role in pathogenesis