echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Study of Nervous System > JNNP: methionine homozygosity for PRNP polymorphisms and susceptibility to human prion disease

    JNNP: methionine homozygosity for PRNP polymorphisms and susceptibility to human prion disease

    • Last Update: 2022-05-24
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Human prion disease is a fatal transmissible spongiform encephalopathy caused by the accumulation of abnormal prion proteins in the central nervous system


     The association of the PRNP polymorphism at codon 129 with susceptibility to prion disease is well known


    This article was published in the Journal of Neurology, Neurosurgery & Psychiatry .


    Prion disease experts organized a monitoring committee consisting of neurologists, neurosurgeons, psychiatrists, neurologists, radiologists and epidemiologists


    Prion disease experts organized a monitoring committee consisting of neurologists, neurosurgeons, psychiatrists, neurologists, radiologists and epidemiologists


    Research Process

    Research Process

    All patients enrolled in the database from April 1999 to February 2021 were eligible for the study


    The codon 129 polymorphisms are divided into two categories: Met/Met and others (Met/Val and Val/Val)



    Codon 129 methionine homozygotes and the occurrence of hereditary prion diseases

    The independent effect of the PRNP polymorphism at codon 129 on prion disease development was estimated, adjusting for the codon 219 polymorphism and other potential confounders


    The independent effect of the PRNP polymorphism at codon 129 on prion disease development was estimated, adjusting for the codon 219 polymorphism and other potential confounders


    KosamiK ,AeR ,HamaguchiT , et alMethionine homozygosity for PRNP polymorphism and susceptibility to human prion diseasesJournal of Neurology, Neurosurgery & PsychiatryPublished Online First:  06 April 2022.


    Kosami  K ,  Ae  R ,  Hamaguchi  T Kosami  KKosami Ae  RAe Hamaguchi  THamaguchi, et al  Methionine homozygosity for PRNP polymorphism and susceptibility to human prion diseasesJournal of Neurology, Neurosurgery & Psychiatry  Published Online First:  06 April 2022.




    leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.