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According to the 129-bit crypton polymorphism and abnormal type of viral protein (PRNP) gene, creutzfeldt-Jakob disease (sCJD) is divided into six types (MM1 / MM2 / MV1 / MV2 / VV1 / VV2) pr protein (PrPSc).
nearly 70% of sCJD patients have MM1 or MV1, have a typical sCJD esogeosis, and other sCJD forms of clinical pathology esopeology is different from the typical MM1, MV1 type KYA disease.
MM2 type sCJD (MM2-sCJD) is the most common type of sCJD with atypical esogeope in Japan.
MM2-sCJD is divided into MM2-cortogenic (MM2C), MM2-masculis (MM2T) and MM1-2C.
using conventional sCJD diagnostic standards (EU) standards and WHO standards, the authors found that clinical diagnosis of MM2C-sCJD (MM2C-sCJD) was difficult, and that the initial diagnosis in most MM2C-sCJD patients included diseases other than SCJD, such as Alzheimer's disease and depression.
with regard to MM2T-sCJD, clinical diagnosis is also difficult.
to develop useful diagnostic criteria for MM2-sCJD, the authors analyzed registered and non-pr virus disease patients who were monitored for the virus disease nationwide in Japan.
method: The authors reviewed the results of the Creutzfeldt-Jakob disease surveillance study conducted in Japan from April 1999 to September 2019, which included 254 pathologically proven cases of viral disease, 9 of which were MM2C-sCJD and 10 mm2T sCJD (MM2T-SCJD).
confirmed patients with hereditary and accessive viral diseases through neuropathological examinations and PRNP genetic analysis.
EEG responsible members rate periodic spire wave groups (PSWCs) on electroencephalograms (EEGs) as "typical" or "recommended."
typical cases are "positive".
the recommended cases, the Committee reviewed and discussed the EEG findings to determine whether the PSWC was "positive" or "negative".
in the cerebral cortical layer, mri diffusion-weighted images examine high-intensity lesions of the substrate nerve sections and hyalural brain.
high signals for MRIs are defined by neuroradiologists (MH) experts.
in three patients, cerebral blood flow (CBF)-SPECT was conducted using 99mTc-cysteine ethyl dismedialymers, and in two (patients) N-isopropyl-to-iodine amphetamine was studied in CBF-SPECT.
the value of the 14-3-3 protein in the cerebrospinal fluid (CSF) through ELISA.
tested the total tau protein in the CSF sample.
results: According to conventional sCJD standards, until death, 4 out of 9 MM2C patients.
7 out of 10 MM2T-sCJD patients were diagnosed with possible sCJD.
compared to other types of sCJD, MM2C-sCJD patients showed slow progression and cortological distribution of high-intensity lesions in the dispersion-weighted image of brain MRI.
mm2T-sCJD patients also showed relatively slow progress and negative results for most of the currently established sCJD diagnostic studies.
in order to clinically diagnose MM2C-sCJD, the authors proposed new standards.
the diagnostic sensitivity and specificity of MM2C-sCJD and other subtypes of sCJD, genetic or accessibility of were virus disease and non-viral disease control were 77.8% and 98.5%, respectively.
mm2T-sCJD, its clinical and laboratory characteristics are not sufficient to develop its diagnostic standards.
Amaguchi T, Sanjo N, Ae R, et al MM2-type sporadic Creutzfeldt-Jakob disease: new diagnostica for MM2-cortical type Journal of Neurology, Neurosurgery and Psimsy Published Online First: 24 August 2020. doi: 10.1136/jnnp-2020-323231 Source: MedSci Originals !-- End of Content Presentation -- !-- To Determine If Login Ends.